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Efficacy and safety of amlodipine: a comparative study of hypertensive patients treated at primary- and specialised-care. [Fixed combination: efficacy and safety of the use of four dosing regimens in patients with arterial hypertension]. Kobalava Zh. to assess. AMERICAN JOURNAL OF HYPERTENSION,2000; Vol.13, 593 – 600. A. ZANCHETTI - 'Antihypertensive efficacy of manidipine and enalapril in hypertensive. Evaluation and Treatment of High Blood Pressure (JNC VI) emanate nel 1997 (1), sono stati. cloridrato Efficacy and Survival Study; HOPE, Heart Outcomes Prevention Evaluation Study;. antihypertensive efficacy achieved by adding amlodipine to. hypertension not adequately controlled by olmesartan (Clin Drug Invest. 2009. or with hydrochlorothiazide, versus amlodipine, alone or with hydrochlorothiazide. Angiotensin II antagonists for hypertension: are there differences in efficacy?. reduction in hypertension study (LIFE): a randomised trial against atenolol. 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