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Benedini, E. Passeri, A. Tufano. Changes induced by zinc on thyroxine deiodination by rat liver in vivo and in vitro. Effects of amiodarone on 5'-deiodination of thyroxine to tri-iodothyronine in. smatici, antiaritmici (amiodarone) o fa- maci antitiroidei (metimazolo, propil-. mental changes in rat brain 5'-deiodinase and thyroid hormones during the fetal. Tissue metabolism of thyroid hormones: deiodinases, transporters and receptors. 19:00. Cocktail di Benvenuto e Visita al Teatro Anatomico. Società di Cardiologia (Gruppo di Studio su amiodarone e tireopatie, coordinato da F. Santeusanio) e. Defects of iodotirosine deiodination. 5′-deiodinase AbM AbTg AbTPO Actinomycin activation decay Amino Acid In-corporation amiodarone Amiodarone Arginine vasopressin atrium Carcinoid. Amiodarone, a drug used to treat cardiac arrhythmias, can cause thyroid. It is also a potent inhibitor of 5′-deiodinase, preventing conversion of T4 to T3. 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