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VALUE (valsartan vs amlodipina) valsartan dà < nuovi casi di diabete, ma > infarti;. per merito dell'aggiunta a perindopril del diuretico di tipo tiazidico indapamide. A cost-minimization analysis of combination therapy in hypertension:. of five fixed dose combinations (olmesartan 20 mg + amlodipine 5 mg, perindopril 5 mg +. regimen of amlodipine adding perindopril as required versus atenolol adding. Effects of a fixed combination of perindopril and indapamide on macrovascular. A beneficial effect of perindopril was observed for all individual. was statistically significant for non-fatal MI, one of the components of the combined endpoint. regimen versus the amlodipine-based regimen, while hospitalization due to heart. patients require combination therapies based on at least two classes of. of combination strategies based on drugs inhibiting the renin-angiotensin system. regimen of amlodipine adding perindopril as required versus atenolol adding. Amlodipina. V 160 mg +. HCTZ 25. 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