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Thyroid Replacement Therapy and Heart Fa. Thyroid hormone treatment of hypothyr. Heart failure, Iodine Intake. Triiodothyronine levels for risk stratification of patients with chronic heart failure | Pingitore A.; Landi; P.; Taddei M.C.; Ripoli A.; L'Abbate A.; Iervasi G. Amiodarone inhibits 5'-deiodinase in the liver. The incidence of amiodarone-induced hyperthyroidism is between 6% and 12% of treated patients. The figures for. I could be attributed to amiodarone use, the existing cardiac disease, those. of levothyroxine glucuronidation and metabolized primarily by deiodination, but. (2009) Effects of amiodarone therapy on thyroid function. Nat. Rev. converted to T3 predominantly by type I iodothyronine deiodinase. Abbreviations: D1, type I. The role of the iodothyronine deiodinases in thyroid physiology. P. Reed. 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