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Bonora; Slide 2; CNS Penetration-Effectiveness Ranks: Standard of evidence 4321 NRTIs Zidovudine AbacavirLamivudineDidanosine. Zidovudine and ursodeoxycholic acid conjugation: design of a new prodrug potentially able to bypass the active efflux transport systems of the central nervous. mass by enhanced permeability and retention (ePr) and neuro- degenerative. 8) Coupling of the antiviral agent zidovudine to polyaspartamide and in vitro. Maurizio DE MARTINO. Professore ordinario; Dipartimento di Scienze della Salute (DSS); - Pediatria generale e specialistica. 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