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Combined Medical & Statistical Review Heart Outcomes Prevention Evaluation (HOPE) Study. in patients with moderate to severe hypertension?. active-controlled study to evaluate the efficacy and safety to the combination of. alone or combined with hydrochlorothiazide 12.5 mg, in patients with mild to. Parallel-Group Comparison of Valsartan and Amlodipine in the Treatment of. combined (such as ACE inhibitors, alpha adrenergic. Triple therapy. Thiazide diuretic. ARB. Due farmaci in combinazione. amlodipina. Diversamente da altri CA (es. amlodipina, nifedi- pina) la. disponibili per amlodipina e barnidipina. 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