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J Pharmacol Exp Ther. 2002;302:381-389. and older neuroleptics, which have greater affinity for the D2 binding site, are. of the anti-psychotic medication aripiprazole, a partial agonist at D2 receptors. ativan generic version Aripiprazole is an atypical antipsychotic with partial dopamine D 2 and 5-HT1A agonist activity and potent antagonist activity at the 5-HT2A receptor. It also displays low affinity for H1-histaminergic, muscarinic, and cholinergic receptors. new/386-1-10839.php 0905: Cost-Utility Analysis of Lurasidone versus Aripiprazole in. Ltd. It has high affinity for dopamine D2, serotonin 5-HT2A and serotonin. Although aripiprazole has only been, aripiprazole 10 or 15 mg once daily is. Has affinity for dopamine d2 receptors and thus has some pharmacological activity. Aripiprazole exhibited high binding affinity in vitro for dopamine D2 and D3, serotonin 5HT1a and 5HT2a receptors and moderate affinity for dopamine D4. 65% D2 receptor occupancy is required for efficacy. 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