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Class III anti-arhythmic drugs for the heart, such as amiodarone and sotalol, block potassium channels in the heart (these channels are. α) e la subunità accessoria chiamata K channel interacting protein (KChIP2). per prolungamento del QT indotto da amiodarone o da malattie miocardiche. Effects of long-term β-blocker therapy on QT variability index in subjects with. Classe III: ibutilide, dofetilide, sotalolo, amiodarone, dronedarone, vernakalant. Classe IV: diltiazem. Direct vasodilators: hydralazine, minoxidil, calcium channel blockers. Nitroprussiate. Adenosine, magnesium, potassium. Diuretic drugs. Amiodarone hydrochloride, a class III antiarrhythmic agent, shows ß blocker-like and potassium channel blocker-like actions on the sinuatrial and atrioventricular. Acetazolamide, amiodarone, amiloride, bepridil, betaxololo, captopril, diltiazem, nalapril. Ion channels in epilepsy. Am J Physiol 1986; 251 (1): R91-6; Bertino M, Beauchamp GK, Engelman K. 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