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Avian influenza virus subtype H5N1, which has been associated with the human disease. resistance to amantadine and rimantadine has increased from 0.4 [. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, N Engl J Med 361, 2009. resistant to amantadine and rimantadine. • Median. new/3141-1-6342.php There may be some flu seasons during which amantadine is not recommended because certain flu strains may be resistant to this drug. Amantadine is also used. An Influenza AH3 Outbreak in a Hospital, Nara Prefecture. 197 Short Communication Frequency of Amantadine-Resistant Influenza A Virus Isolated from. 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