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Dopamine Hypothesis. D4 receptors. Aripiprazole is a partial agonist at DA2 and 5HT1a receptors, claimed to represent a “new generation” of antipsychotics. Abilify, Restlessness, agitation and akathisia. Dopamine, serotonin and all other neurotransmitter circuits are. Some neuroleptics are known as serotomimetic drugs, affecting serotonin receptors – some block the receptors and some. Especially in the elderly, both partial remissions and relapses are. In lay terms, then, it can both enhance dopamine and serotonin signaling. Abilify is an INCOMPLETE D2 blocker, not a “partial agonist”. A novel strategy in order to regulate dopamine CNS circuitries is based on dopamine partial agonism. A dopamine partial agonist can be conceptualized as a. 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