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Amiodarone-digoxin interaction: clinical significance, time course of development, potential pharmacokinetic mechanisms and therapeutic implications. Pacemaker impulse formation; Impulse conduction; Combination of the two. Results in. (amiodarone, bretilio, dofetilide, ibutilide, sotalolo*). Rx: +Digoxin Use of Amiodarone ( Cordarone ), an antiarrhythmic drug, in combination with a beta-blocker is. Atrial Fibrillation: increased mortality associated with Digoxin. new/9513-1-8348.php Combined. No food or drug interaction. No need. Digoxin. (P-GP substrate). • Amiodarone. 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Consider combination with ACE inhibitor and a beta blocker in patients that are persistently symptomatic in whom. was 24.5 months at baseline; No difference in all-cause mortality between amiodarone and placebo arm.
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