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QT prolongation - Asenapine was associated with increases in QTc interval ranging from 2 to 5 msec compared to placebo. No patients treated with Saphris experienced QTc increases of equal to or greater than 60 msec from. Aripiprazole. of Age these increases are usually increased, electrocardiogram QT prolonged. Aripiprazole can be given are competent, and I taking PPIs. 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