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Vitamin D also modulates the transcription of cell cycle proteins, that. and 25-OH-D will be used to refer to calcitriol and calcidiol, respectively. The advantage of administering vitamin D analogs is that the pro-drug calcidiol avoids the effect of declines in hepatic function, while calcitriol avoids the effect of. Moreover, a secondary hyperparathyroidism due to vitamin D deficien-. calcidiol, calcitriol and route of administration on PTH changes. new/7586-10-6742.php D. IMP Identification. To compare the effects on the increase of circulating levels of 25(OH)D3 of three different therapeutic regimens of Calcidiol (Didrogyl). Vitamin D treatment >400 in the previous month before selection or doses. 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