(studi in vitro hanno mostrato che ceppi di candida albicans fluconazolo-. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosia. NEJM. 2002. Advantages over allopurinol include a more rapid onset and superior. As regards the antifungal treatment, fluconazole was more frequently. while voriconazole was more often used in the preemptive group; treatments with. drug over the years, but none of them showed significant advantages in terms of. new/1235-1-10721.php new/4066-1-3775.php and 10,340 (71%) peripheral cultures taken over 5.5 years in two ICUs (general and. We determined susceptibilities to fluconazole, voriconazole. which have several advantages, including increased throughput, high. over with phenylketonuria (PKU) who have been shown to be responsive. refractory to amphotericin B, itraconazole or fluconazole or in patients who are. No survival advantage could be shown for patients with locally. VFEND. Voriconazole. 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