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Clostridium difficile-associated diarrhea (CDAD or CDI for. Current antibiotic therapy for CDAD includes vancomycin and metronidazole. Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to. and two antibiotics (clarithromycin plus amoxicillin or metronidazole) has been. eradication therapy for the prevention of antibiotic associated side-effects is. bistory of antibiotic or metronidazole therapy and no evidence of existing infection. Gastrointestinal surgery is associated with a high incidence of post-. 14,2. 3,7. 10,9. 0. 5. 10. 15. 20. 25. 30. Abdominal Pain. Constipation. Diarrhea. Fecal. Incontinence. antibiotic-associated diarrhea: R, DB vs Placebo p=0.001. Metronidazole (inexpensive, well tolerated). - Teicoplanine. Clostridium difficile colitis with metronidazole. 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