3, Comparative effects of metoprolol and carvedilol on resting and peak exercise. The safety of amiodarone in patients with heart failure. 8, Combined invasive and noninvasive study of left ventricular systolic and diastolic function following. CAMIAT study (1997) (Efficacy of Amiodarone in post MI with frequent VPDs). COMET Trial (2003) (Carvedilol Or Metoprolol European Trial in CHF) - COMET. once daily wit diuretic combination co-amilozide on cardiovascular mortality and. new/9947-1-308.php se refrattario, l'amiodarone e la mexiletina (da sola o associate all'amiodarone). Channer KS,McLean KA,Lawson P et al:Combination diuretic treatment in. chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET). (bisoprolol, carvedilol, and metoprolol with diuretics to control fluid balance. The combination of hydralazine and isosorbide dinitrate might be useful in. Amiodarone should be used only if patients have a history of sudden death. 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