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Resistance of Influenza A Virus to Amantadine and Rimantadine: Results of One Decade of Surveillance. chemotherapy The life cycle of influenza virus Amantadine and rimantadine. Intermediate metabolism Antibiotic resistance Bacteria have short generation. new/8268-1-16972.php or inhibitors of the viral M2 protein, such as amantadine and rimantadine. However, virus strains have emerged that show drug resistance to both classes of. like Oseltamavir (Tamiflu ® ) and Zanamivir (Relenza ® ) whereas drugs like amantadine and rimantadine are to be used since the virus is resistant to them. CDC Recommends against the Use of Amantadine and Rimantadine for the. (2006) High levels of adamantane resistance among influenza A (H3N2) viruses. The two most widely used antiviral agents today are for. one of the factors involved in causing cisplatin resistance in ovarian cancer. oseltamivir, or inhibitors of the viral M2 protein, such as amantadine and rimantadine. 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