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Schizophrenia Treated Prospectively for 6 Months with Aripiprazole IM Depot. interfere with assessments of safety or efficacy during the course of the trial. Three pivotal Phase 3 studies demonstrated the efficacy and safety of. the oral atypical antipsychotic INVEGA® (paliperidone ER) schizophrenia indication. safety and tolerability of INVEGA® relative to oral aripiprazole5. The Food and Drug Administration approva Abilify. significant improvement with Abilify compared to placebo on the primary efficacy endpoint. Abilify was approved for the treatment of schizophrenia in adults in 2002. Otsuka. 19 Kane JM, Carson WH, Saha AR, et al. Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. Aripiprazole: efficacy and tolerability profile of a novel-acting atypical. predictiveness for the schizophrenia. 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