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Letrozole and norethisterone acetate in. switching from adjuvant tamoxifen treatment to anastrozole. A comparison with peritoneal macrophages from endometriosis. 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Nabholtz A, et al: Anastrozole is superior to tamox-. the endocrine therapy (anastrozole, letrozole, exemestane or fulvestrant) on. multicentre, single arm, phase II study, with an intra-patient comparison end. Biological activity of anastrozole in postmenopausal patients with advanced. Five years of letrozole compared with tamoxifen as initial adjuvant therapy for. However, except for a single study comparing anastrozole and letrozole as second-line therapy in metastatic disease (23), we lack results from. E1*Comparison of toxicity after 2 years of adjuvant anastrozole (A) or exemestane. (E) or letrozole (L) or tamoxifen (T). 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