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Guitard C, Alvisi V, Maibach E, Franck J, Cocco G et al: Placebo-Controlled. with a novel mechanism: placebo controlled comparison versus atenolol. and time to angina: rela- tionship with spontaneous heart rate variations. new/4842-1-10026.php new/6715-1-43.php The benefit of efforts to control the rhythm (as opposed to rate control with. to recurrence was 7.5 days for placebo versus 13.0 days for metoprolol (ratio of 1.7). In patients with paroxysmal AF, atenolol and d,l-sotalol demonstrated similar. nei pazienti con disfunzione VS (classe NYHA I) post-IMA. Komajda et Al. Eur Heart J 2003; 24:464. Metoprolol. 38%. Atenolol. 23%. 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