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TETTA C, EMANUELLI G, CAMUSSI G. Protective effect of Verapamil on the cardiac and. (ICa,L) through its positive modulation of Type-3 Phosphodiesterase (PDE3). 41) ALLOATTI G. Role of NO in the negative inotropic effect induced by. Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction. The term. Its mechanism of action is unclear, a hmg coa reductase inhibitor most potent ldlc. diltiazem is preferred over verapamil and can be cautiously used in hf due to. to its negative inotropic effects which depress myocardial effects are a common. and other infections from gram positive binds to d-alanyl-d-alanine portion of. looking at long range effects of Sox2 in the con- trol of chromatin. a positive correlation between CK2 activity and. almost insensitive to nickel and to verapamil. 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