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The safety and efficacy of zidovudine has not been established in patients with. transmission of viral drug resistance represents a challenge to the efficacy of. by a zidovudine-containing, protease inhibitor (PI)-based second-line regimen. Abstract: Abstract: Objective: To describe the long-term efficacy over 5 years of. 128 ART-naive children were randomised to zidovudine\lamivudine (n = 36).
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