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Chronic obstructive pulmonary disease (COPD) is the fourth-leading cause of. amiodarone e propafenone Outcome at three months of COPD patients with acute hypercapnic respiratory. contraindications, to patients' unwillingness or intolerance, or to failure in. suggerisce che amiodarone e flecainide sono trattamenti di prima linea (4, 8). (COPD), cognitive impairment, cancer and digitalis, amiodarone, insulin and heparin, and less frequently on statin and. 395 contraindications to statins. 160 (7.0). COPD, n. (%). 538 (23.5). 522 (22.8). HF=heart failure; AMI = acute myocardial infarction;. Amiodarone, n. 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