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L'amantadina che si ritrova ad alte concentrazioni nei lisosomi cellulari, bloccando il. Rimantadine: 1993. Differenti. Resistant mutants (altered polymerase). acquisto purinethol new/8181-1-12840.php L'Amantadina (Mantadan® – Roche) e il suo derivato metilato. High Levels of Adamantane Resistance Among Influenza A (H3N2) Viruses and. Webber-Jones J. A controlled trial of amantadine and rimantadine in the. Surveillance of amantadine and oseltamivir resistance among influenza viruses. The effectiveness and safety of amantadine (AMT) and rimantadine (RMT) for. Both rimantadine and the similar drug amantadine are derivates of adamantane. pandemic flu samples tested have shown resistance to rimantadine and it is. new/5133-1-15915.php Measured resistance to the standard antiviral drugs amantadine and rimantadine in h3n2 has increased from 1% in 1994 to 12% in 2003 to 91% in 2005. Amantadine and rimantadine bind to a site within the pore of the M2 tetrameric. 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