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Aripiprazole (OPC-14597) as Maintenance Treatment in Patients With. Adjunctive Therapy in Adults With Major Depression Associated with Bipolar I. Effectiveness of lithium in subjects with treatment-resistant depression and suicide risk: results and lessons of an underpowered randomised clinical trial. Bipolar disorder, Seroquel is effective for both the manic and the depressive phases. For the first time. Aripiprazole for maintaining efficacy in bipolar I disorder. Effectiveness of second-generation antipsychotics: a naturalistic, randomized. Aripiprazole, Ziprasidone, and Quetiapine in the Treatment. 6.4 Efficacy in the treatment of bipolar depression. 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