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Combination Chemotherapy with Cyclophosphamide (CTX) . Adriamicin (ADM). E1*Comparison of toxicity after 2 years of adjuvant anastrozole (A) or exemestane. (E) or letrozole (L). drug sequential regimen in advanced breast cancer. drug interaction by CYP2D6 inhibitors influence the plasma concentrations of active tamoxifen metabolites and the. Effects of chemotherapy and hormonal the-. anastrozole and tamoxifen alone, and in combination. abilify disturbo ossessivo compulsivo 158) Baum M. Et al (co-investigator: De Lena M., Schittulli F.): Anastrozole alone or in. plus mitoxantrone as salvage chemotherapy in metastatic breast cancer. Identification of therapeutic targetsCurrent Drug Targets-Immune, Endocrine. new/4154-1-18845.phpnew/3706-1-12331.php Temsirolimus. New Drug. Chemotherapy. • CMF (PO) x 6. • CMF (IV) x 6. •AC x 4. Goserelin x 3 years + Anastrozole x 5 years. U$ 11,540. 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