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Use of proton pump inhibitors in ear1y pregnancy and the risk of binh defects. Randomized Tria1 of Omeprazole or Ranitidine Versus P1accbo in the. (article in Harefuah 2004; 143: 820–824; 837; Chan VS. Pregnancy outcome after exposure to ranitidine and other H2-blockers. The safety of proton pump inhibitors in pregnancy: a multicentre prospective controlled. 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