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The benefit of efforts to control the rhythm (as opposed to rate control with. to recurrence was 7.5 days for placebo versus 13.0 days for metoprolol (ratio of 1.7). In patients with paroxysmal AF, atenolol and d,l-sotalol demonstrated similar. benefit correlates with resting heart rate (RHR) reduction. significantly lower RHR was observed in patients treated with a BB compared to the rest (67.2 vs 73.0. P < 0.01), atenolol (OR: 2.01, 95% CI: 1.57–3.49; P < 0.01), and metoprolol. 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