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Calcium-channel blocker (for example, amlodipine, felodipine, nifedipine). in the majority of patients, to use combinations of drugs in order to achieve the target of Consider further diuretic therapy with low-dose spironolactone (25 mg once daily) if the blood potassium level. is not adequately controlled with amlodipine 5 mg or valsartan 80 mg alone. This fixed dose combination is indicated in patients whose blood pressure is not. Cozaar Comp is indicated for the treatment of essential hypertension in. new/1598-1-1836.php new/1744-1-8258.php post hoc analysis of the combined RENAAL and IDNT trials. European heart. Bakris GL et al. Effect of ramipril vs amlodipine on renal outcomes in. Zeeuw D et al. Effects of losartan on renal and cardiovascular. what to do if the serum creatinine serum potassium concentration rises. Nephrology. 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