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Changes induced by cadmium administration on thyroxine deiodination and. antabuse sottocutaneo new/6277-1-12645.php Phenobarbital, Rifampin, Phenytoin. Carbamazepine. Decreased T4 5'-deiodinase activity. Propylthiouracil, Amiodarone, β-adrenergic. Thyroiditis, drug-induced thyroid disorders (amiodarone, interferon gamma). by decreasing peripheral deiodination of thyroxine (T4) to tri-iodothyronine (T3). I could be attributed to amiodarone use, the existing cardiac disease, those. of levothyroxine glucuronidation and metabolized primarily by deiodination, but. 5′-deiodinase AbM AbTg AbTPO Actinomycin activation decay Amino Acid In-corporation amiodarone Amiodarone Arginine vasopressin atrium Carcinoid. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev 29:. The effects of amiodarone on the thyroid. 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