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Digoxin Antiarrhythmic, miscellaneous. CATEGORY:C BREAST FEEDING:Compatible [G3]. The toxicity of this combination was confirmed in pregnant rabbits [7]. Interaction Between Digoxin and Amiodarone Steven Haffa, RPh. Volume IX, Issue 12. Disorders of cardiac rhythm requiring antiarrhythmic therapy generally. Bajaj BP, Baig MW, Perrins EJ. Amiodarone-induced torsades de pointes: the possible facilitatory role of digoxin. Torsades de pointes and QT prolongation due to a combination of loratadine and amiodarone. Pacing Clin Electrophysiol. 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