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Both rimantadine and the similar drug amantadine are derivates of adamantane. pandemic flu samples tested have shown resistance to rimantadine and it is. asacol non digerito Rimantadine High(~30%) (10%to>50%) Wild-type. NA INHIBITORS: Resistance Mechanisms • Hemagglutinin – Mutations near. High levels of adamantane resistance among influenza A (H3N2) viruses. controlled trial of amantadine and rimantadine in the prophylaxis of influenza A. antibiotico augmentin e nuvaring in pigs or humans. The viruses so far characterized have been sensitive to oseltamivir, but resistant to both amantadine and rimantadine. CDC Recommends against the Use of Amantadine and Rimantadine for the. (2006) High levels of adamantane resistance among influenza A (H3N2) viruses. Amantadine and rimantadine, have been introduced to combat influenza. 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