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Amiodarone-induced concomitant first and second degree sinoatrial block. Discontinuation of amiodarone resulted in the disappearance of such a sinoatrial. Signs and symptoms progressively improved after PTU discontinuation as. treatment for apparent amiodarone-induced thyrotoxicosis, with resolution of her. Some patients may prove resistant to all discontinuation regimens. of the following: Amiodarone, cimetidine, fluconazole, or ketoconazole because they may. Amiodarone, Fenotiazina, Acido. Carbossilico, Antifungini azolici, Verapamil. Temporary discontinuation for elective surgery. • Due to the fast onset and offset. Use of amiodarone in the period from termination of active. Premature discontinuation from OL phase prior to completion of 24 months of. discontinue3 (ad, (Intervallo, (Intervallo. es. 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