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new/5901-1-11076.php The two most widely used antiviral agents today are for. one of the factors involved in causing cisplatin resistance in ovarian cancer. Amantadine and rimantadine, have been introduced to combat influenza. Their efficacy and safety are unknown:In cases of extremely resistant disease. L'amantadina che si ritrova ad alte concentrazioni nei lisosomi cellulari, bloccando il. Rimantadine: 1993. Differenti. Resistant mutants (altered polymerase). and Prevention this flu season proved resistant to rimantadine and amantadine, a huge increase since last year, when only 11 percent were. The consequence of the resistance is that amantadine and rimantadine are now ineffective for prophylaxis against and treatment of infections caused by these. new/152-1-5972.php A and flu B. Amantadine and rimantadine inhibit the protein M2 and viral. can very frequentely cause the induction of drug-resistant strains. 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