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Stroke is a leading cause of death and the primary. “Aspirin and extended-release dipyridamole versus clopidogrel for recurrent. combinations in patients with hypertension and diabetes”. Conclusion Picotamide is significantly more effective than aspirin in. of aspirin and dipyridamole in preventing disease progression and. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent. *ONgoing Telmisartan Alone and in combination with Ramipril. ASPIRINA nella Prevenzione Primaria delle CVD. Aspirin plus dipyridamole versus aspirin. No difference in combined death and stroke. Dipyridamole was introduced into clinical medicine in the early 1960s as a coronary. agent used for secondary stroke prevention in combination with aspirin. 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