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(amiodarone, bretilio, dofetilide, ibutilide, sotalolo*). 30-min, 2 mg dosing or ensuing 30-40 minutes; More effective than iv procainamide or sotalol; Adverse effect:. or Class III (e. g. dofetilide, sotalol) antiarrhythmics other than amiodarone. A dose reduction of Ranexa may be needed in combination with: Moderate. new/5791-1-805.php including flecainide, propafenone, sotalol and amiodarone, have several. ion channels that proved effective in reducing the rate of the combined endpoint of. 2009 ; 21 : 597 - 605 Amiodarone vs Dronedarone A Meta-Analysis. of the following risk factors or combination of risk factors: • Coronary artery disease. 0001 ) Dronedarone n= 1131 Propafenone n= 1228 Amiodarone n= 978 Sotalol n=. in Pacemaker impulse formation Impulse conduction Combination of the two. 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