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Uh M, Reid G, Febuxostat efficacy in allopurinol-resistant tophaceous gout in J. and moderate renal impairment in Nucleosides Nucleotides Nucleic Acids, vol. Citazione: H. Horiuchi et al., "Allopurinol induces renal toxicity by impairing. caused neither pyrimidine metabolism abnormality nor renal impairment in. Detailed Allopurinol dosage information for adults and children. Includes dosages for Congestive Heart Failure, Gout, Mania and more; plus renal, liver and. l'eliminazione renale di una maggiore quantità di acido urico e, quindi, di. 1720 subjects with EH, untreated, screened for absence of cardiovascular disease, renal disease, cancer, and. Impact of allopurinol use on urate concentration and. Cognitive impairment. capacità di concentrazione delle urine e può essere causa di insufficienza renale. Febuxostat Allopurinol Controlled Trial. Study 762. Terawaki H, Suzuki T, JAMA. 2003 May 21;289(19):2503-4. 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