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Is the combination of an ARB and ACE-inhibitor more efficacious than ACE-inhibitor. Interaction Between Digoxin and Amiodarone Steven Haffa, RPh. Volume IX, Issue 12. Disorders of cardiac rhythm requiring antiarrhythmic therapy generally. OBIETTIVO: Questo studio randomizzato prospettico si propone di valutare e confrontare gli effetti profilattici di amiodarone rispetto digossina e combinazione. allegra allegra d generic allegra drug interaction. amiodarone digoxin and amiodarone interaction. amiodarone amiodarone and digoxin combination Mechanism of Interaction: Multiple theories exist, but actual mechanism is unknown. Amiodarone may decrease the clearance of digoxin, resulting in prolonged. Per la nota tossicità e non conclusiva evidenza di efficacia, l'amiodarone non deve. and their combination in congestive heart failure: Randomized Evaluation of. Valagussa F. 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