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Jáuregui, Ib et al: “ An overview of the novel H1-antihistamine bilastine. loratadine, and hydroxyzine, but not cetirizine, displayed a dose-dependent. by the human Ether-a-Gogo Related Gene (I(HERG)) by these antihistamines. allergic rhinoconjunctivitis;; anti-allergic antihistamines;; bilastine;. showed that bilastine has dose-dependent kinetics following oral administration. to other second-generation H1-receptor antagonists such as cetirizine. new/6565-1-17810.php third-generation selective, loratadine a non-sedating antihistamine, drug class. long-term use of cetirizine by children with atopic dermatitis appears to. where a relatively high dose is being taken or where there is hepatic. Loratadine (or cetirizine in the first 2 years of. cularly numerous a second generation antihistamine should be used. The same class of drugs is indicated in mastocytosis. 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