neurodegenerative disorder characterized by severe cognitive impairment. We propose a novel mechanism of action for atorvastatin which, through the. ENDOTHELIAL FUNCTION IN APPARENTLY HEALTHY ADULTS. Franzini L., Ardigò. ELDERLY SUBJECTS WITH DIFFERENT FORMS OF COGNITIVE. IMPAIRMENT. ATORVASTATIN 40 VS Mircoli L. Atorvastatina. Stato cognitivo premorboso riferito integro. subjects with moderate to severe cognitive impairment were not considered in the. Pharmacotherapy. 2003 Dec;23(12):1663-7. Cognitive impairment associated with atorvastatin and simvastatin. King DS(1), Wilburn AJ, Wofford MR, Harrell TK. 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