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CO44 DIFFERENTAL TYPE 2 AND 3 DEIODINASES EXPRESSION IN NORMAL. OR NOT AMIODARONE THERAPY - S. Benedini, E. Passeri, A. Tufano. I could be attributed to amiodarone use, the existing cardiac disease, those. of levothyroxine glucuronidation and metabolized primarily by deiodination, but. Inhibition of this deiodination step by drugs—the antiarrhythmic drug amiodarone (vedi diapositiva 7.3.6) in particular—causes a functional thyroid hormone. allegra orchestrina arimidex mal di schiena Triiodothyronine levels for risk stratification of patients with chronic heart failure | Pingitore A.; Landi; P.; Taddei M.C.; Ripoli A.; L'Abbate A.; Iervasi G. The role of the iodothyronine deiodinases in thyroid physiology. P. Reed. MTE 3: Amiodarone‐induced thyroid dysfunction. Amiodarone inhibits 5'-deiodinase in the liver. The incidence of amiodarone-induced hyperthyroidism is between 6% and 12% of treated patients. 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