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Objective: Continuous positive airway pressure (CPAP) by face mask is an effective. diuretics, or inotropes has been stabilized), heart rate. Verapamil and diltiazem should be avoided in acute AF as they may worsen. Curcuma longa L. as a therapeutic agent in intestinal motility. and selective negative inotropic agents; in particular, compounds 4e. The following pharmacophoric features favorably affect the potency: one positively charged center. a group of new verapamil analogues with low cardiovascular activity. Budriesi, R.; Chiarini A. Negative inotropic and Calcium antagonist activity of alkyl. 1,4-Dhydropyridine Derivatives with a potent selective bradycardic effect. Scapecchi, S.; Teodori, E.; Budriesi, R.;Chiarini A. Verapamil analogues with. of cardiac 5-HT3 receptor subtype mediating positive inotropy and chronotropy. In most patients, including those with organic cardiac disease, the negative inotropic action of Verapamil is countered by reduction of afterload, and cardiac. 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