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Effects of H1 antihistamines on adhesion molecules: a possibile rationale. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults. A dose range of 20 to 30 is recommended. Zyrtec (cetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Zyrtec is an antihistamine used to treat both seasonal and perennial allergy symptoms such as watery eyes, runny nose (rhinitis), itching eyes. Cetirizine is also used to treat hives. Your doctor may prescribe a lower dose of this medication. 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