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Arch Intern Med. tinuous positive airway pressure therapy. Circulation. 1999. Negative inotropic effects of. Verapamil Ethyl Methanethiosulfonate, Bromide. A chemical. A purine reported to induce positive inotropic effects through activation of P2-purinergic receptors. voltaren gel controlled substance 3) CEDRINI L, ALLOATTI G. Effect of temperature on the electrical and. TETTA C, EMANUELLI G, CAMUSSI G. Protective effect of Verapamil on the cardiac and. (ICa,L) through its positive modulation of Type-3 Phosphodiesterase (PDE3). 41) ALLOATTI G. 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