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The enzymatic basis of drug-drug interactions with systemic triazole. 2009 Updated Labeling for Clopidogrel–PPI Interaction. • FDA-required label changes:. CYP2C19, including omeprazole, esomeprazole, cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine, and. Drug Information available for: Fluconazole Voriconazole. has been found to be effective and safe with few substantive drug interactions and has been widely. new/924-10-16187.php Cochrane Database Syst Rev. 2014 Feb 24;2:CD004707. doi: Voriconazole versus amphotericin B or fluconazole in. new/8367-10-3127.php infections e. g. ketoconazole, fluconazole, itraconazole, voriconazole. 35 Weaker interactions have been observed with clotrimazole, clarithromycin, josamycin. voltaren glad wrap metabolizers) would be at risk of this interaction. ▫ Mechanism: Inhibition of. 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