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P < 0.01), atenolol (OR: 2.01, 95% CI: 1.57–3.49; P < 0.01), and metoprolol. Cocco G, Chu D: The Anti-Ischemic Effect of Metoprolol in Patients with Chronic Angina. Guitard C, Alvisi V, Maibach E, Franck J, Cocco G et al: Placebo-Controlled. with a novel mechanism: placebo controlled comparison versus atenolol. and time to angina: rela- tionship with spontaneous heart rate variations. Rate control consists of controlling the ventricular rate to slow down its response. classes of rate control agents consist of; beta-blockers (metoprolol, atenolol. switching from metoprolol to atenolol for sinus tachy. It worked well to control my heart rate, but I have had issues with. (~70 vs ~80) The Effects of Atenolol and Metoprolol on Survival Rate of Patients with Mild-to-Moderate. atenolol (78%) was greater than survival rate of patients from the control group (48%). 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