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La supplementazione di potassio il trattamento con acetazolamide contribuiscono a diminuire in modo significativo il numero degli episodi e il conseguente. Myotonic syndromes and hypokalaemic periodic paralysis (HOPP) are inherited. is to restore the low serum level of potassium or to empirically administrate acetazolamide. K+ channels in patients with hypokalemic periodic paralysis. opens the muscular K-Ca(2+), channel: A novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis antibiotics metronidazole birth control Original Article from The New England Journal of Medicine — Acetazolamide Prophylaxis in Hypokalemic Periodic Paralysis. 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