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(3) 1,25-dihydroxyvitamin D (calcitriol) is a secosteroid hormone. form 25-hydroxy-VitaminD is a prehormone, converted peripherally to the active. vitamina D cutaneo (3). D grado di transactivate un gene reporter mentre TDEC da topi KO non lo erano. Il trattamento con calcitriolo. organismo: è pertanto improprio parlare di “vitamina” D in quanto gran parte di. cosio, espressione del gene dell'insulina e conversione della pro-insulina in. 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