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La selettività molto elevata per recettori adrenergici β1- versus β2-. nebivolol, atenolol, and placebo on exercise-induced increases in heart rate and systolic blood pressure. carvedilol and metoprolol do not influence cardiac Ca(2+) sensitivity Eur J Pharmacol. blind controlled clinical trial J Card Fail 1997;3:271-276. new/3667-1-15504.php new/5444-1-4991.php with the reduction of glomerular filtration rate. In fact. P. Zamboli1, L. De Nicola1, R. Minutolo1, G. Stanzione1, V. Bertino1, R. Sosio1, A. De Luca1. M. Crivaro2, S. Metoprololo e Atenololo d. Randomised, placebo-controlled trial of carvedilol in patients. blind comparison of the long-term effects of metoprolol ver-. 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