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Partial dopamine agonists in the treatment of psychosis. Unmet needs in the treatment of schizophrenia: the role of aripiprazole. agonist at dopamine D2 and at serotonin 5-HT1A receptors and an antagonist at. It is a dopamine D2- and D3-receptor partial agonist, with higher affinity for D3. of these agents (including aripiprazole, clozapine, olanzapine, paliperidone. I ET AL: "TRANSDERMAL ADMINISTRATION OF THE DOPAMINE AGONIST N-04476A1 *,,, Alkermes, Inc. Aripiprazole. A deuterated version of Aripiprazole, a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. 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